![]() ![]() Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag).Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (Transcript Variant 4) protein (His tag).Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 420-529) protein (GST tag).Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 1-613) protein (GST tag).Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 103-322) protein (His tag).Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 102-612) protein (His tag). ![]() Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1) (AA 102-613) protein (His tag).Glycosylation from GlyGen ( O95831) 1 site, 1 O-linked glycan (1 site) Ubiquitination at Lys109, Lys189, and Lys255 Ubiquitination at Lys-255 by XIAP/BIRC4 blocks its ability to bind DNA and induce chromatin degradation, thereby inhibiting its ability to induce cell death. Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation. AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner. During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). RARA ZNF571 ZEB2 NR2F1 ZFP69B ZNF366 ZNF512 PRDM10 BCOR PRDM1 ZNF280C AIFM1 ELF4 RBMX2 BCORL1 SASH3 HSALNG0140106 HSALNG0140108 RAB33A RF00017-8272ĮPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER SP1 ZNF580 POLR2A DPF2 KLF17 NCOR1 ZNF184 ZNF600 YY1 RESTĮNSG00000286650 AIFM1 RAB33A BCORL1 UTP14A SMARCA1 OCRL RBMX2 ELF4 ZNF280CĭPF2 JUND CTCF POLR2A ZNF600 ZIC2 REST ZNF592 TBP MAX Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed: 26004228). In contrast, participates in normal mitochondrial metabolism. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed: 19418225). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed: 17094969). Binds to DNA in a sequence-independent manner (PubMed: 27178839). caspase-independent fragmentation of chromosomal DNA (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. UniProtKB/Swiss-Prot Summary for AIFM1 Geneįunctions both as NADH oxidoreductase and as regulator of apoptosis (PubMed: 20362274, 23217327, 17094969). ![]()
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